Antimicrobial properties of silver-containing wound dressings: a microcalorimetric study

O'Neill, M.A.A., Vine, G.J., Beezer, A.E., Bishop, A.H., Hadgraft, J., Labetoulle, C., Walker, M. and Bowler, P.G. (2003) Antimicrobial properties of silver-containing wound dressings: a microcalorimetric study. International Journal of Pharmaceutics, 263 . pp. 61-68. 10.1016/S0378-5173(03)00361-2 .

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DOI: 10.1016/S0378-5173(03)00361-2


The studies reported here have been undertaken to assess the potential use of isothermal microcalorimetry in studying the antimicrobial efficacy of wound dressings that contain antimicrobial agents. The microcalorimetric technique allows non-invasive and non-destructive analysis to be performed directly on a test sample, regardless of whether it is homogeneous or heterogeneous in nature. Microcalorimetry is an established procedure that offers quantitative measurements and has the distinct advantage over traditional antimicrobial test methodologies in that calorimetric measurements are made continuously over real-time, thus the dynamic response of microorganisms to an antimicrobial agent is observed in situ. The results described in this paper are for interaction of two silver-containing wound care products AQUACEL® Ag Hydrofiber® (ConvaTec, Deeside, UK) and Acticoat™ 7 with SILCRYST™ (Smith and Nephew Healthcare, UK) with the wound pathogenic organisms Staphylococcus aureus and Pseudomonas aeruginosa. Both dressings are shown, microcalorimetrically, to have the capacity to kill these common wound pathogens within 1–2 h of contact. A dose–response study was conducted with the AQUACEL Ag dressing. Microcalorimetry is shown to be rapid, simple and effective in the study of the antimicrobial properties of gel forming wound dressings.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Uncontrolled Keywords:Calorimetry; Wound dressings; Silver; Antibacterial
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1024
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:05 Jun 2008 12:15
Last Modified:03 Nov 2011 10:48

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