Thomson, A.M. (2003) Presynaptic frequency- and pattern-dependent filtering. Journal of Computational Neuroscience, 15 . pp. 159-202. 10.1023/A:1025812808362 .
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Dual intracellular recordings from pairs of synaptically connected neurones have demonstrated that the frequency-dependent pattern of transmitter release varies dramatically between different classes of connections. Somewhat surprisingly, these patterns are not determined by the class of neurone supplying the axon alone, but to a large degree by the class of postsynaptic neurone. A wide range of presynaptic mechanisms, some that depress the release of transmitter and others that enhance release have been identified. It is the selective expression of these different mechanisms that determines the unique frequency- and pattern-dependent properties of each class of connection. Although the molecular interactions underlying these several mechanisms have yet to be fully identified, the wealth and complexity of the protein-protein and protein-lipid interactions that have been shown to control the release of transmitter suggest many ways in which the properties of a synapse may be tuned to respond to particular patterns and frequencies.
|Additional Information:||Full text available electronically at the School of Pharmacy Library.|
|Uncontrolled Keywords:||synapse, fusion core complex, facilitation, depression, transmitter release|
|Departments, units and centres:||Department of Pharmacology > Department of Pharmacology|
|Journal or Publication Title:||Journal of Computational Neuroscience|
|Deposited By:||Library Staff|
|Deposited On:||21 Aug 2006|
|Last Modified:||11 Nov 2011 15:51|
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