Investigation of the permeability characteristics of peri-ulcer and whole ischaemic skin tissue.

Walker, M., Hadgraft, J. and Lane, M.E. (2008) Investigation of the permeability characteristics of peri-ulcer and whole ischaemic skin tissue. International Journal of Pharmaceutics, 357 . pp. 1-5. 10.1016/j.ijpharm.2008.01.063.

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DOI: 10.1016/j.ijpharm.2008.01.063


Excessive wound exudate in chronic wounds can cause skin maceration to occur around a wound, which may delay healing and lead to other complications. In order to assess possible treatment options with topical therapy there is a need to characterize the permeability of wound and peri-ulcer tissue. Previously we have reported the permeability of a range of chemicals with differing physicochemical properties in human ulcerated and peri-ulcer ischaemic tissue. The findings suggested that wound tissue and peri-ulcer tissue were not representative of normally functioning skin barriers. In the present work we have investigated the permeability of tritiated water in peri-ulcer and whole skin human tissue obtained from clinically diagnosed diabetic ischaemic patients. Permeability data for peri-ulcer tissue was generally higher and more variable than for normal tissue. Histological examination confirmed the breakdown of the skin tissue in the peri-ulcer area and also in the normal skin tissue samples taken from diabetic ischaemic patients. The impaired skin barrier function both in the peri-ulcer and normal tissue may offer opportunities for dermal and transdermal therapies for management of diabetes-related complications.

Item Type:Article
Additional Information:Full text available in print and electronically from the School of Pharmacy Library.
Uncontrolled Keywords:Wound; Peri-ulcer; Skin; Permeability; Topical delivery; Transdermal delivery
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1136
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:18 Mar 2009 16:54
Last Modified:03 Nov 2011 11:36

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