Walker, M., Hadgraft, J. and Lane, M.E. (2008) Investigation of the permeability characteristics of peri-ulcer and whole ischaemic skin tissue. International Journal of Pharmaceutics, 357 . pp. 1-5. 10.1016/j.ijpharm.2008.01.063.
Full text not available from this repository.
Excessive wound exudate in chronic wounds can cause skin maceration to occur around a wound, which may delay healing and lead to other complications. In order to assess possible treatment options with topical therapy there is a need to characterize the permeability of wound and peri-ulcer tissue. Previously we have reported the permeability of a range of chemicals with differing physicochemical properties in human ulcerated and peri-ulcer ischaemic tissue. The findings suggested that wound tissue and peri-ulcer tissue were not representative of normally functioning skin barriers. In the present work we have investigated the permeability of tritiated water in peri-ulcer and whole skin human tissue obtained from clinically diagnosed diabetic ischaemic patients. Permeability data for peri-ulcer tissue was generally higher and more variable than for normal tissue. Histological examination confirmed the breakdown of the skin tissue in the peri-ulcer area and also in the normal skin tissue samples taken from diabetic ischaemic patients. The impaired skin barrier function both in the peri-ulcer and normal tissue may offer opportunities for dermal and transdermal therapies for management of diabetes-related complications.
|Additional Information:||Full text available in print and electronically from the School of Pharmacy Library.|
|Uncontrolled Keywords:||Wound; Peri-ulcer; Skin; Permeability; Topical delivery; Transdermal delivery|
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||International Journal of Pharmaceutics|
|Deposited By:||Library Staff|
|Deposited On:||18 Mar 2009 16:54|
|Last Modified:||03 Nov 2011 11:36|
Item downloaded times since 18 Mar 2009 16:54.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item