Application of microemulsions in dermal and transdermal drug delivery.

Santos, P., Hadgraft, J. and Lane, M.E. (2008) Application of microemulsions in dermal and transdermal drug delivery. Skin Pharmacology and Physiology, 21 (5). pp. 246-259. 10.1159/000140228.

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DOI: 10.1159/000140228

Abstract

Microemulsions are thermodynamically stable colloidal dispersions of water and oil stabilized by a surfactant and, in many cases, also a cosurfactant. In the pharmaceutical field, microemulsions have been used as drug carriers for percutaneous, ocular, oral and parenteral administration. This review discusses some of the applications of microemulsions specifically for topical and transdermal applications. Microemulsion nomenclature and composition, with particular emphasis on choice of surfactant and cosurfactant, is discussed. Methods used to characterize microemulsions are reviewed. Microemulsion formulations for dermal and transdermal delivery of pharmaceutical agents with particular emphasis on anti-inflammatory and anaesthetic agents are critically evaluated. Finally, the issues which warrant further investigation by researchers in order to realize the full potential of the technology are discussed.

Item Type:Article
Uncontrolled Keywords:Microemulsions Topical delivery Transdermal delivery Skin
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1137
Journal or Publication Title:Skin Pharmacology and Physiology
Deposited By:Library Staff
Deposited On:19 Mar 2009 14:44
Last Modified:03 Nov 2011 11:40

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