Neidle, S. and Parkinson, G.N. (2008) Quadruplex DNA crystal structures and drug design. Biochimie, 90 (8). pp. 1184-1190. 10.1016/j.biochi.2008.03.003.
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DOI: 10.1016/j.biochi.2008.03.003
Abstract
Crystallographic studies of G-quadruplex nucleic acids have resulted in a small group of structures to date. Their morphological and detailed conformational features are described here, emphasizing the stability of the G-tetrad core and the flexibility of loops, especially upon ligand binding. Implications for drug design are discussed, in the context of the druggability of both telomeric and non-telomeric quadruplex DNAs.
| Item Type: | Article |
|---|---|
| Additional Information: | Full text available electronically from the School of Pharmacy Library. |
| Uncontrolled Keywords: | Crystallography; Drugs; Quadruplex |
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group |
| ID Code: | 1193 |
| Journal or Publication Title: | Biochimie |
| Deposited By: | Library Staff |
| Deposited On: | 29 Apr 2009 11:23 |
| Last Modified: | 16 Mar 2012 09:15 |
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