Neidle, S. and Parkinson, G.N. (2008) Quadruplex DNA crystal structures and drug design. Biochimie, 90 (8). pp. 1184-1190. 10.1016/j.biochi.2008.03.003.
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Crystallographic studies of G-quadruplex nucleic acids have resulted in a small group of structures to date. Their morphological and detailed conformational features are described here, emphasizing the stability of the G-tetrad core and the flexibility of loops, especially upon ligand binding. Implications for drug design are discussed, in the context of the druggability of both telomeric and non-telomeric quadruplex DNAs.
|Additional Information:||Full text available electronically from the School of Pharmacy Library.|
|Uncontrolled Keywords:||Crystallography; Drugs; Quadruplex|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group|
|Journal or Publication Title:||Biochimie|
|Deposited By:||Library Staff|
|Deposited On:||29 Apr 2009 11:23|
|Last Modified:||16 Mar 2012 09:15|
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