Functionalized-Quantum-Dot–Liposome Hybrids as Multimodal Nanoparticles for Cancer

Al-Jamal, W.T., Al-Jamal, K.T., Bomans, P.H., Fredericks, P. and Kostarelos, K. (2008) Functionalized-Quantum-Dot–Liposome Hybrids as Multimodal Nanoparticles for Cancer. Small, 4 (9). pp. 1406-1415. 10.1002/smll.200701043.

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DOI: 10.1002/smll.200701043


Functionalized-quantum-dot-liposome (f-QD-L) hybrid nanoparticles are engineered by encapsulating poly(ethylene glycol)-coated QD in the internal aqueous phase of different lipid bilayer vesicles. f-QD-L maintain the QD fluorescence characteristics as confirmed by fluorescence spectroscopy, agarose gel electrophoresis, and confocal laser scanning microscopy. Cationic f-QD-L hybrids lead to dramatic improvements in cellular binding and internalization in tumor-cell monolayer cultures. Deeper penetration into three-dimensional multicellular spheroids is obtained for f-QD-L by modifying the lipid bilayer characteristics of the hybrid system. f-QD-L are injected intratumorally into solid tumor models leading to extensive fluorescent staining of tumor cells compared to injections of the f-QD alone. f-QD-L hybrid nanoparticles constitute a versatile tool for very efficient labeling of cells ex vivo and in vivo, particularly when long-term imaging and tracking of cells is sought. Moreover, f-QD-L offer many opportunities for the development of combinatory therapeutic and imaging (theranostic) modalities by incorporating both drug molecules and QD within the different compartments of a single vesicle.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Uncontrolled Keywords:liposomes;quantum dots;spheroid penetration;tumor imaging;theranostics
Departments, units and centres:Department of Pharmaceutics > Centre for Drug Delivery Research
ID Code:1241
Journal or Publication Title:Small
Deposited By:Library Staff
Deposited On:03 Feb 2011 09:57
Last Modified:04 May 2012 10:52

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