Interfacing functionalized carbon nanohorns with primary phagocytic cells.

Lacotte, S., Garcia, A., Decossas, M., Al-Jamal, W.T., Li, S. and Kostarelos, K. (2008) Interfacing functionalized carbon nanohorns with primary phagocytic cells. Advanced Materials, 20 (2). pp. 2421-2426. 10.1002/adma.200702753.

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DOI: 10.1002/adma.200702753


Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Uncontrolled Keywords:carbon nanostructures;cells;cytotoxicity;drug delivery
Departments, units and centres:Department of Pharmaceutics > Centre for Drug Delivery Research
ID Code:1252
Journal or Publication Title:Advanced Materials
Deposited By:Library Staff
Deposited On:29 Jun 2009 14:40
Last Modified:04 May 2012 10:32

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