Al-Jamal, W.T., Al-Jamal, K.T. and Kostarelos, K. (2008) Abstract: Self-assembled lipid-nanocrystal vesicle hybrids as theranostic devices for cancer. In: 236th ACS National Meeting, 17-21 August 2008, Philadelphia, USA.
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Nanocrystals are novel nanomaterials that have been used to label cells in vitro or tissues in vivo. Seeking novel multimodal therapeutics, we have demonstrated that a variety of nanocrystals and lipid components can self-assemble into nanoscale, lipid-nanocrystal vesicle hybrids which were successfully used to label cells in vitro and tumor xenografts in vivo. Moreover, we assessed the fate and interaction of the lipid-nanocrystal vesicle hybrids with the biological milieu in animal models after local and systemic administration. Tissue biodistribution, affinity and blood pharmacokinetic parameters were found to be dependent on multiple factors, primarily governed by the nanocrystal characteristics and the lipid coat components. By varying such parameters, we could develop and evaluate pharmacologically various lipid-nanocrystal vesicle hybrid systems of versatile features. The data obtained indicates that such lipid-nanocrystal hybrids can be considered as effective, biocompatible platforms for combinatory diagnostic and therapeutic biomedical applications.
|Item Type:||Conference or Workshop Item (Paper)|
|Departments, units and centres:||Department of Pharmaceutics > Centre for Drug Delivery Research|
|Deposited By:||Library Staff|
|Deposited On:||01 Jul 2009 11:39|
|Last Modified:||04 May 2012 10:51|
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