Prospective observational study of adverse drug reactions to diclofenac in children.

Standing, J.F., Ooi, K., Keady, S., Howard, R.F., Savage, I. and Wong, I.C.K. (2009) Prospective observational study of adverse drug reactions to diclofenac in children. British Journal of Clinical Pharmacology, 68 (2). pp. 243-251. 10.1111/j.1365-2125.2009.03447.x.

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DOI: 10.1111/j.1365-2125.2009.03447.x


AIM The aim of this study was to investigate the type of common (occurring in >1% of patients) adverse reactions caused by diclofenac when given to children for acute pain. METHODS A prospective observational study was undertaken on paediatric surgical patents aged ≤12 years at Great Ormond Street and University College London Hospitals. All adverse events were recorded, and causality assessment used to judge the likelihood of them being due to diclofenac. Prospective recruitment meant not all patients were prescribed diclofenac, allowing an analysis of utilization. Causality of all serious adverse events was reviewed by an expert panel. RESULTS Children prescribed diclofenac were significantly older, and stayed in hospital for shorter periods than those who were not. Diclofenac was not avoided in asthmatic patients. Data on 380 children showed they suffer similar types of nonserious adverse reactions to adults. The incidence (95% confidence interval) of rash was 0.8% (0.016, 2.3); minor central nervous system disturbance 0.5% (0.06, 1.9); rectal irritation with suppositories 0.3% (0.009, 1.9); and diarrhoea 0.3% (0.007, 1.5). No serious adverse event was judged to be caused by diclofenac, meaning the incidence of serious adverse reactions to diclofenac in children is <0.8%. CONCLUSION Children given diclofenac for acute pain appeared to suffer similar types of adverse reactions to adults; the incidence of serious adverse reaction is <0.8%.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Uncontrolled Keywords:acute pain;adverse drug reaction;children;diclofenac;drug utilization
Departments, units and centres:Department of Practice and Policy > Department of Practice and Policy
ID Code:1312
Journal or Publication Title:British Journal of Clinical Pharmacology
Deposited By:Library Staff
Deposited On:21 Dec 2009 14:40
Last Modified:20 Oct 2011 12:12

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