Hsia, Y.F., Neubert, A.C., Rani, F., Viner, R.M., Hindmarsh, P.C. and Wong, I.C.K. (2009) An increase in the prevalence of type 1 and 2 diabetes in children and adolescents: results from prescription data from a UK general practice database. British Journal of Clinical Pharmacology, 67 (2). pp. 242-249. 10.1111/j.1365-2125.2008.03347.x.
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AIMS Despite evidence of an increase in the incidence of both type 1 and type 2 diabetes in youths, there are few data on the prevalence of either type in children and adolescents. The aim of this study was to investigate the prevalence of childhood diabetes over an 8-year period in the UK. METHODS This was a retrospective cohort study that covered 8 years (January 1998 to December 2005) of UK IMS Disease Analyzer (IMS DA) data. The cohort comprised all children and adolescents aged 0–18 years who received at least one antidiabetic drug prescription during the study period. The prevalence of antidiabetic drug prescribing was used as a proxy for diabetes itself. RESULTS Data were available on 505 754 children aged 0–18 years and a total of 37 225 antidiabetic prescriptions were issued. Insulin use increased significantly from 1.08 per 1000 children [95% confidence interval (CI) 0.96, 1.20] in 1998 to 1.98 (95% CI 1.80, 2.10) in 2005 (P < 0.001), more markedly in those aged 12 and 18 years. The use of oral antidiabetic drugs for diabetes treatment rose significantly from 0.006 per 1000 children in 1998 (95% CI 0.0043, 0.017) to 0.05 (95% CI 0.025, 0.080) (P < 0.001) in 2005. CONCLUSIONS This study indicates a significant increase in prevalence on both type 1 and type 2 diabetes treatment in children and adolescents in the UK. Thus, this supporting evidence from other sources that the prevalence of childhood diabetes is rising rapidly. Further epidemiological studies are required to investigate the aetiology and risk factors.
|Additional Information:||Full text available electronically from the School of Pharmacy Library. The definitive version is available at www.3.interscience.wiley.com The definitive version is available at www3.interscience.wiley.com.|
|Uncontrolled Keywords:||antidiabetic drugs;diabetes;epidemiology;paediatric;prevalence drugs;diabetes;epidemiology;paediatric;prevalence|
|Departments, units and centres:||Department of Practice and Policy > Centre for Paediatric Pharmacy Research|
|Journal or Publication Title:||British Journal of Clinical Pharmacology|
|Deposited By:||Library Staff|
|Deposited On:||15 Jan 2010 15:54|
|Last Modified:||20 Oct 2011 12:11|
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