Selectivity in ligand recognition of G-quadruplex loops.

Campbell, N.H., Patel, M., Tofa, A., Ghosh, R., Parkinson, G.N. and Neidle, S. (2009) Selectivity in ligand recognition of G-quadruplex loops. Biochemistry, 48 (1). pp. 1675-1680. 10.1021/bi802233v.

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DOI: 10.1021/bi802233v


A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group
ID Code:1332
Journal or Publication Title:Biochemistry
Deposited By:Library Staff
Deposited On:19 Jan 2010 15:52
Last Modified:04 Nov 2011 17:25


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