Campbell, N.H., Patel, M., Tofa, A., Ghosh, R., Parkinson, G.N. and Neidle, S. (2009) Selectivity in ligand recognition of G-quadruplex loops. Biochemistry, 48 (1). pp. 1675-1680. 10.1021/bi802233v.
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DOI: 10.1021/bi802233v
Abstract
A series of disubstituted acridine ligands have been cocrystallized with a bimolecular DNA G-quadruplex. The ligands have a range of cyclic amino end groups of varying size. The crystal structures show that the diagonal loop in this quadruplex results in a large cavity for these groups, in contrast to the steric constraints imposed by propeller loops in human telomeric quadruplexes. We conclude that the nature of the loop has a significant influence on ligand selectivity for particular quadruplex folds.
| Item Type: | Article |
|---|---|
| Additional Information: | Full text available electronically from the School of Pharmacy Library. |
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group |
| ID Code: | 1332 |
| Journal or Publication Title: | Biochemistry |
| Deposited By: | Library Staff |
| Deposited On: | 19 Jan 2010 15:52 |
| Last Modified: | 04 Nov 2011 17:25 |
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