Cardiac troponin I in isoproterenol-induced cardiac injury in the Hanover Wistar rat; studies on low dose levels and routes of administration.

Brady, S., York, M., Scudamore, C., Williams, T., Griffiths, W.J. and Turton, J.A. (2010) Cardiac troponin I in isoproterenol-induced cardiac injury in the Hanover Wistar rat; studies on low dose levels and routes of administration. Toxicologic Pathology . 10.1177/0192623309357948.

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DOI: 10.1177/0192623309357948

Abstract

The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptance of cTnI as a cardiac biomarker. At 2 hr postdosing with 0-500 μg/kg ISO, mean serum cTnI levels were increased in a dose-related fashion at ≥10 μg/kg with no evidence of cardiac pathology. At 24 h, cTnI concentrations were generally at control levels, but histologic cardiomyocyte injury was evident in a proportion of the animals given ≥10 μg/kg. In a second experiment, rats given SC ISO at 5,000 μg/kg and necropsied at 0, 1, 2, and 4 hr postdosing had higher levels of serum cTnI than animals given the same dose IP.

Item Type:Article
Uncontrolled Keywords:biomarkers cardiac troponin I cardiotoxicity isoproterenol rat toxicity
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:1411
Journal or Publication Title:Toxicologic Pathology
Deposited By:Library Staff
Deposited On:10 Feb 2010 14:45
Last Modified:24 Feb 2012 11:22

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