Brady, S., York, M., Scudamore, C., Williams, T., Griffiths, W.J. and Turton, J.A. (2010) Cardiac troponin I in isoproterenol-induced cardiac injury in the Hanover Wistar rat; studies on low dose levels and routes of administration. Toxicologic Pathology . 10.1177/0192623309357948.
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The current studies demonstrate the effect of low-dose intraperitoneal (IP) administration of isoprotenerol (ISO) and subcutaneous (SC) versus IP routes of administration of ISO on serum cardiac troponin I (cTnI) levels in female Hanover Wistar rats, providing additional evidence to support acceptance of cTnI as a cardiac biomarker. At 2 hr postdosing with 0-500 μg/kg ISO, mean serum cTnI levels were increased in a dose-related fashion at ≥10 μg/kg with no evidence of cardiac pathology. At 24 h, cTnI concentrations were generally at control levels, but histologic cardiomyocyte injury was evident in a proportion of the animals given ≥10 μg/kg. In a second experiment, rats given SC ISO at 5,000 μg/kg and necropsied at 0, 1, 2, and 4 hr postdosing had higher levels of serum cTnI than animals given the same dose IP.
|Uncontrolled Keywords:||biomarkers cardiac troponin I cardiotoxicity isoproterenol rat toxicity|
|Departments, units and centres:||Department of Pharmacology > Centre for Toxicology|
|Journal or Publication Title:||Toxicologic Pathology|
|Deposited By:||Library Staff|
|Deposited On:||10 Feb 2010 14:45|
|Last Modified:||24 Feb 2012 11:22|
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