Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats.

Waterfield, C.J., Turton, J.A., Scales, M.D.C. and Timbrell, J.A. (1993) Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats. Archives of Toxicology, 67 (4). pp. 244-254. 10.1007/BF01974343.

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DOI: 10.1007/BF01974343

Abstract

The effect of various hepatotoxicants on urinary taurine and urinary creatine has been studied in the rat. Several hepatotoxic agents, carbon tetrachloride, thioacetamide, galactosamine and allyl alcohol which all caused hepatic necrosis (sometimes accompanied by steatosis), resulted in a rise in urinary taurine and in some cases creatine, when administered to rats. Ethionine and hydrazine also raised urinary taurine but caused only steatosis and did not raise urinary creatine. Therefore urinary taurine and possibly creatine may be useful markers of liver injury and dysfunction. Liver taurine levels were also affected by some of the hepatotoxicants but in those cases where there was a rise in urinary taurine this could not be accounted for by the loss in liver taurine. It is suggested that the increase in urinary taurine is partly due to changes in protein synthesis and hence in sulphur amino acid metabolism caused by hepatotoxic agents. However, bromobenzene did not increase urinary taurine and-naphthylisothiocyanate and lithocholate caused reduced levels. It is suggested that this lack of increase in urinary taurine may be due to depletion of glutathione or interference with the biliary system.

Item Type:Article
Uncontrolled Keywords:Carbon tetrachloride - Thioacetamide - Hydrazine - Ethionine,-Naphthylisothiocyanate - Allyl alcohol - Bromobenzene - Lithocholate - Taurine - Creatine - Urine - Hepatotoxicity - Biomarkers
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:1418
Journal or Publication Title:Archives of Toxicology
Deposited By:Library Staff
Deposited On:11 Feb 2010 10:08
Last Modified:24 Feb 2012 11:33

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