Antibacterial diterpenes from Plectranthus ernstii.

Stavri, M., Paton, A., Skelton, B.W. and Gibbons, S. (2009) Antibacterial diterpenes from Plectranthus ernstii. Journal of Natural Products, 72 (6). pp. 1191-1194. 10.1021/np800581s.

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DOI: 10.1021/np800581s

Abstract

Three new diterpenoids including two pimaranes (1 and 2) and a labdane (3) were isolated from the whole herb of Plectranthus ernstii. The structures of these compounds were determined as rel-15(ζ),16-epoxy-7α-hydroxypimar-8,14-ene (1) and rel-15(ζ),16-epoxy-7-oxopimar-8,14-ene (2), and compound 3 was elucidated as 1R,11S-dihydroxy-8R,13R-epoxylabd-14-ene on the basis of single-crystal X-ray structural analysis. Compound 1 exhibited moderate antistaphylococcal activity against a range of multidrug-resistant (MDR) and methicillin-resistant (MRSA) strains of Staphylococcus aureus with a minimum inhibitory concentration (MIC) of 32 μg/mL. All three diterpenes exhibited antimycobacterial activity against three strains of rapidly growing mycobacteria with MIC values ranging from 8 to 128 μg/mL.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:1421
Journal or Publication Title:Journal of Natural Products
Deposited By:Library Staff
Deposited On:12 Feb 2010 10:37
Last Modified:09 Mar 2012 15:41

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