Reduction of liver taurine in rats by beta-alanine treatment increases carbon tetrachloride toxicity.

Waterfield, C.J., Turton, J.A., Scales, M.D.C. and Timbrell, J.A. (1993) Reduction of liver taurine in rats by beta-alanine treatment increases carbon tetrachloride toxicity. Toxicology, 77 (1-2). pp. 7-21. 10.1016/0300-483X(93)90133-D.

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DOI: 10.1016/0300-483X(93)90133-D

Abstract

Treatment of rats with β-alanine increases the urinary levels and markedly reduces the concentration of taurine in the liver. Dosing with carbon tetrachloride (CCL4) during treatment with β-alanine results in a marked decrease in urinary taurine concomitant with a decrease in food intake. Treatment of animals with β-alanine increases the hepatotoxicity of single doses of CCL4 as determined histologically and by measurement of serum alanine transaminase (ALT) and aspartate transaminase (AST) levels. Urinary creatine is also raised significantly after the administration of CCL4 in β-alanine-treated animals. However, the accumulation of triglycerides (TRIG) in the liver caused by dosing with CCL4 was not influenced by β-alanine treatment. The data suggest that liver taurine levels may be an important factor in determining the degree of CCL4-induced cellular necrosis but not hepatic triglyceride accumulation.

Item Type:Article
Uncontrolled Keywords: Taurine; β-Alanine; Carbon tetrachloride; Hepatotoxicity; Liver; Increased susceptibility
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:1424
Journal or Publication Title:Toxicology
Deposited By:Library Staff
Deposited On:15 Feb 2010 09:31
Last Modified:24 Feb 2012 11:34

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