The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage.

Waterfield, C.J., Turton, J.A., Scales, M.D.C. and Timbrell, J.A. (1993) The correlation between urinary and liver taurine levels and between pre-dose urinary taurine and liver damage. Toxicology, 77 (1-2). pp. 1-5. 10.1016/0300-483X(93)90132-C .

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DOI: 10.1016/0300-483X(93)90132-C

Abstract

Analysis of data from several studies has shown that urinary taurine levels are highly significantly correlated with liver taurine concentration in control rats. Furthermore, urinary taurine levels measured before dosing with various hepatotoxic agents are significantly correlated with serum AST and ALT values measured after dosing with hepatotoxicants. That is, animal with low urinary taurine values and therefore low liver taurine concentrations tend to show greater hepatic damage. These data suggest that taurine may have a protective function in the liver.

Item Type:Article
Uncontrolled Keywords:Taurine; Liver; Hepatotoxicity; Urinary marker; Prediction of susceptibility
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:1425
Journal or Publication Title:Toxicology
Deposited By:Library Staff
Deposited On:15 Feb 2010 09:38
Last Modified:24 Feb 2012 11:36

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