Waterfield, C.J., Turton, J.A., Scales, M.D.C. and Timbrell, J.A. (1993) Effects of various non-hepatotoxic compounds on urinary and liver taurine levels in rats. Archives of Toxicology, 67 (8). pp. 538-546. 10.1007/BF01969266.
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Administration of compounds which alter protein synthesis or sulphur amino acid metabolism in rats results in changes in the excretion of urinary taurine. Treatment with diethylmaleate (DEM) or phorone, which will deplete glutathione (GSH), reduces taurine excretion, whereas treatment with buthionine sulphoximine (BSO), which will inhibit glutathione synthesis, increases taurine excretion. Treatment with cycloheximide, an inhibitor of protein synthesis, increases taurine excretion, whereas pretreatment with phenobarbital, which will increase protein synthesis, decreases taurine excretion. Administration of agents which damage organs other than the liver such as the kidney, heart and testes, does not increase urinary taurine.
|Uncontrolled Keywords:||Rats - Taurine - Urine levels - Liver|
|Departments, units and centres:||Department of Pharmacology > Centre for Toxicology|
|Journal or Publication Title:||Archives of Toxicology|
|Deposited By:||Library Staff|
|Deposited On:||15 Feb 2010 09:54|
|Last Modified:||24 Feb 2012 11:39|
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