Effects of various non-hepatotoxic compounds on urinary and liver taurine levels in rats.

Waterfield, C.J., Turton, J.A., Scales, M.D.C. and Timbrell, J.A. (1993) Effects of various non-hepatotoxic compounds on urinary and liver taurine levels in rats. Archives of Toxicology, 67 (8). pp. 538-546. 10.1007/BF01969266.

Full text not available from this repository.

DOI: 10.1007/BF01969266

Abstract

Administration of compounds which alter protein synthesis or sulphur amino acid metabolism in rats results in changes in the excretion of urinary taurine. Treatment with diethylmaleate (DEM) or phorone, which will deplete glutathione (GSH), reduces taurine excretion, whereas treatment with buthionine sulphoximine (BSO), which will inhibit glutathione synthesis, increases taurine excretion. Treatment with cycloheximide, an inhibitor of protein synthesis, increases taurine excretion, whereas pretreatment with phenobarbital, which will increase protein synthesis, decreases taurine excretion. Administration of agents which damage organs other than the liver such as the kidney, heart and testes, does not increase urinary taurine.

Item Type:Article
Uncontrolled Keywords:Rats - Taurine - Urine levels - Liver
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:1427
Journal or Publication Title:Archives of Toxicology
Deposited By:Library Staff
Deposited On:15 Feb 2010 09:54
Last Modified:24 Feb 2012 11:39

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item