The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus.

Smith, E.C.J., Kaatz, G.W., Seo, S.M., Wareham, N., Williamson, E.M. and Gibbons, S. (2007) The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 51 (12). pp. 4480-4483. 10.1128/AAC.00216-07 .

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DOI: 10.1128/AAC.00216-07

Abstract

The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Subinhibitory concentrations reduced the MICs of selected antibiotics, suggesting that it may also be an efflux pump inhibitor (EPI). A totarol-resistant mutant that overexpressed norA was created to separate antimicrobial from efflux inhibitory activity. Totarol reduced ethidium efflux from this strain by 50% at 15 μM (1/4× MIC), and combination studies revealed marked reductions in ethidium MICs. These data suggest that totarol is a NorA EPI as well as an antistaphylococcal antimicrobial agent.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:1484
Journal or Publication Title:Antimicrobial Agents and Chemotherapy
Deposited By:Library Staff
Deposited On:23 Mar 2010 16:03
Last Modified:18 Nov 2011 16:45

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