Xiao, Z.Y., Mu, Q., Shiu, W.K.P., Zeng, Y.H. and Gibbons, S. (2007) Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Journal of Natural Products, 70 . pp. 1779-1782. 10.1021/np0704147.
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Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N–Q (1–4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.3 µM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 µM.
|Additional Information:||Full text available electronically from the School of Pharmacy Library.|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy|
|Journal or Publication Title:||Journal of Natural Products|
|Deposited By:||Library Staff|
|Deposited On:||23 Mar 2010 16:13|
|Last Modified:||23 Mar 2010 16:13|
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