Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii.

Xiao, Z.Y., Mu, Q., Shiu, W.K.P., Zeng, Y.H. and Gibbons, S. (2007) Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Journal of Natural Products, 70 . pp. 1779-1782. 10.1021/np0704147.

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DOI: 10.1021/np0704147

Abstract

Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N–Q (1–4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.3 µM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 µM.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:1485
Journal or Publication Title:Journal of Natural Products
Deposited By:Library Staff
Deposited On:23 Mar 2010 16:13
Last Modified:23 Mar 2010 16:13

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