Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents.

Antonow, D., Kaliszczak, M., Kang, G.D., Coffils, M.J., Tiberghien, A.C., Cooper, N., Barata, T.S., Heidelberger, S., James, C.H., Zloh, M., Jenkins, T.C., Reszka, A.P., Neidle, S., Guichard, S.M., Jodrell, D.I., Hartley, J.A., Howard, P.W. and Thurston, D.E. (2010) Structure−Activity Relationships of Monomeric C2-Aryl Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) Antitumor Agents. Journal of Medicinal Chemistry, 53 (7). pp. 2927-2941. 10.1021/jm901722v.

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DOI: 10.1021/jm901722v


A comprehensive SAR investigation of the C2-position of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) monomer antitumor agents is reported, establishing the molecular requirements for optimal in vitro cytotoxicity and DNA-binding affinity. Both carbocyclic and heterocyclic C2-aryl substituents have been studied ranging from single aryl rings to fused ring systems, and also styryl substituents, establishing across a library of 80 analogues that C2-aryl and styryl substituents significantly enhance both DNA-binding affinity and in vitro cytotoxicity, with a correlation between the two. The optimal C2-grouping for both DNA-binding affinity and cytotoxicity was found to be the C2-quinolinyl moiety which, according to molecular modeling, is due to the overall fit of the molecule in the DNA minor groove, and potential specific contacts with functional groups in the floor and walls of the groove. This analogue (14l) was shown to delay tumor growth in a HCT-116 (bowel) human tumor xenograft model.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:1506
Journal or Publication Title:Journal of Medicinal Chemistry
Deposited By:Library Staff
Deposited On:09 Apr 2010 16:00
Last Modified:21 Oct 2011 14:45

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