Appendino, G., Arnoldi, L., Mercalli, E., Stavri, M., Gibbons, S., Ballero, M. and Maxia, A. (2004) Anti-mycobacterial Coumarins from Sardinian Giant Fennel (Ferula communis). Journal of Natural Products, 67 (12). pp. 2108-2110. 10.1021/np049706n.
Full text not available from this repository.
The structure of a new prenylated coumarin (E-ω-benzoyloxyferulenol, 1b) from the Sardinian giant fennel (Ferula communis) has been confirmed by synthesis. The parent compound ferulenol (1a) showed sub-micromolar antimycobacterial activity, which was partly retained in 1b and in the simplified synthetic analogue 3, but diminished in its ω-hydroxy and ω-acetoxy derivatives (1c and 1d, respectively). The outstanding activity of 1a, its low toxicity, and the evidence for definite structure−activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation.
|Additional Information:||Full text available electronically from the School of Pharmacy Library.|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy|
|Journal or Publication Title:||Journal of Natural Products|
|Deposited By:||Library Staff|
|Deposited On:||13 Apr 2010 11:04|
|Last Modified:||13 Apr 2010 11:04|
Item downloaded times since 13 Apr 2010 11:04.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item