Anti-mycobacterial Coumarins from Sardinian Giant Fennel (Ferula communis).

Appendino, G., Arnoldi, L., Mercalli, E., Stavri, M., Gibbons, S., Ballero, M. and Maxia, A. (2004) Anti-mycobacterial Coumarins from Sardinian Giant Fennel (Ferula communis). Journal of Natural Products, 67 (12). pp. 2108-2110. 10.1021/np049706n.

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DOI: 10.1021/np049706n


The structure of a new prenylated coumarin (E-ω-benzoyloxyferulenol, 1b) from the Sardinian giant fennel (Ferula communis) has been confirmed by synthesis. The parent compound ferulenol (1a) showed sub-micromolar antimycobacterial activity, which was partly retained in 1b and in the simplified synthetic analogue 3, but diminished in its ω-hydroxy and ω-acetoxy derivatives (1c and 1d, respectively). The outstanding activity of 1a, its low toxicity, and the evidence for definite structure−activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:1515
Journal or Publication Title:Journal of Natural Products
Deposited By:Library Staff
Deposited On:13 Apr 2010 11:04
Last Modified:13 Apr 2010 11:04

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