Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity.

Machado, M., Hadgraft, J. and Lane, M.E. (2010) Assessment of the variation of skin barrier function with anatomic site, age, gender and ethnicity. International Journal of Cosmetic Science . 10.1111/j.1468-2494.2010.00587.x.

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DOI: 10.1111/j.1468-2494.2010.00587.x

Abstract

The skin is the largest organ of the human body and its functions include protection, thermoregulation sensation and secretion. Significant advances in our understanding of how the morphology and physiology of the skin contribute to the skin’s barrier role have been achieved in recent years. The aim of this review is to summarize the principal approaches which have been used to assess variation in skin barrier function with anatomic site, age, gender, and ethnicity. The methods discussed include trans-epidermal water loss (TEWL) measurement, assessment of corneocyte size, response to vasoactive compounds and attenuated total reflectance Fourier transform infrared (ATR-FTIR) interrogation of skin. The utility of the various methods is considered and the most important findings in the literature to date are highlighted.

Item Type:Article
Additional Information:Full text available electronically from the School of Pharmacy Library. The definitive version is available at www3.interscience.wiley.com
Uncontrolled Keywords:attenuated total reflectance Fourier transform infrared;corneocyte;nicotinates;skin barrier function;trans-epidermal water loss
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1632
Journal or Publication Title:International Journal of Cosmetic Science
Deposited By:Library Staff
Deposited On:30 Jun 2010 11:32
Last Modified:03 Nov 2011 10:57

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