Santos, P., Watkinson, A.C., Hadgraft, J. and Lane, M.E. (2010) Oxybutynin permeation in skin: the influence of drug and solvent activity. International Journal of Pharmaceutics, 384 (1-2). pp. 67-72. 10.1016/j.ijpharm.2009.09.043 .
Full text not available from this repository.
The influence of degree of saturation (DS) of oxybutynin on permeation from octyl salicylate (OSAL) or propylene glycol (PG) vehicles was investigated, in vitro, in human skin. The permeation of OSAL and PG was also evaluated and the quantity of drug and solvent in the skin at the end of the diffusion study was measured. For OSAL the permeation of oxybutynin increased linearly with DS of drug for both 25 and 50% OSAL formulations. However, no differences were seen in oxybutynin permeation for formulations with the same DS but with different OSAL amounts, although the drug permeation was always slightly higher for 50% OSAL formulations. There was a decrease in the amount of OSAL extracted from skin with drug concentration (up to 5 DS). There was also a good correlation between the DS calculated from the amount of oxybutynin and OSAL extracted from the skin, and the actual DS of the formulation. In contrast oxbutynin DS did not affect PG permeation and there were no significant differences in oxybutynin permeation for the formulations with different DS. The lack of permeation enhancement for PG formulations appears to be related to PG depletion from the skin. The findings emphasise the importance of maintaining the drug in solution in order to achieve effective permeation from dermal and transdermal formulations.
|Additional Information:||Full text available in print and electronically from the School of Pharmacy Library.|
|Uncontrolled Keywords:||Octyl salicylate; Propylene glycol; Oxybutynin; Skin; Permeation; Supersaturation|
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||International Journal of Pharmaceutics|
|Deposited By:||Library Staff|
|Deposited On:||01 Jul 2010 11:40|
|Last Modified:||03 Nov 2011 12:21|
Item downloaded times since 01 Jul 2010 11:40.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item