Ankli, A., Heilmann, J., Heinrich, M. and Sticher, O. (2000) Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri. Phytochemistry, 54 (5). pp. 531-537. 10.1016/S0031-9422(00)00144-8 .
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From the methanol extract of the roots of Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3β-O-β-6-deoxyguloside (2), 19-hydroxy-sarmentogenin-3β-O-β-6-deoxyguloside (4), sarmentogenin-3β-O-[α-allosyl-(1→4)-β-6-deoxyalloside] (5), and securigenin-3β-O-[α-allosyl-(1→4)-β-6-deoxyalloside] (6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-oic acid methylester (11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.
|Additional Information:||Full text available in print and electronically from the School of Pharmacy Library.|
|Uncontrolled Keywords:||Crossopetalum gaumeri; Celastraceae; Cardenolides; Triterpenes; Diterpene; Cytotoxic activity; Antibacterial activity; Yucatec Maya; Traditional medicine|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy|
|Journal or Publication Title:||Phytochemistry|
|Deposited By:||Library Staff|
|Deposited On:||20 Dec 2010 15:38|
|Last Modified:||07 Oct 2011 12:09|
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