Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri.

Ankli, A., Heilmann, J., Heinrich, M. and Sticher, O. (2000) Cytotoxic cardenolides and antibacterial terpenoids from Crossopetalum gaumeri. Phytochemistry, 54 (5). pp. 531-537. 10.1016/S0031-9422(00)00144-8 .

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DOI: 10.1016/S0031-9422(00)00144-8


From the methanol extract of the roots of Crossopetalum gaumeri, four new highly cytotoxic cardenolides, securigenin-3β-O-β-6-deoxyguloside (2), 19-hydroxy-sarmentogenin-3β-O-β-6-deoxyguloside (4), sarmentogenin-3β-O-[α-allosyl-(1→4)-β-6-deoxyalloside] (5), and securigenin-3β-O-[α-allosyl-(1→4)-β-6-deoxyalloside] (6) were isolated. The dichloromethane extract afforded the new diterpene 3,15-dihydroxy-18-norabieta-3,8,11,13-tetraene (7) as well as the new triterpene 2,3,7-trihydroxy-6-oxo-1,3,5(10),7-tetraene-24-nor-friedelane-29-oic acid methylester (11). The new terpenoids lack cytotoxicity and the antibacterial activity is moderate to low.

Item Type:Article
Additional Information:Full text available in print and electronically from the School of Pharmacy Library.
Uncontrolled Keywords:Crossopetalum gaumeri; Celastraceae; Cardenolides; Triterpenes; Diterpene; Cytotoxic activity; Antibacterial activity; Yucatec Maya; Traditional medicine
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy
ID Code:1719
Journal or Publication Title:Phytochemistry
Deposited By:Library Staff
Deposited On:20 Dec 2010 15:38
Last Modified:07 Oct 2011 12:09

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