Structure of the first parallel DNA quadruplex-drug complex.

Clark, G.R., Pytel, P.D., Squire, C.J. and Neidle, S. (2003) Structure of the first parallel DNA quadruplex-drug complex. Journal of the American Chemical Society, 125 (9). pp. 4066-4067. 10.1021/ja0297988.

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DOI: 10.1021/ja0297988

Abstract

The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5‘ end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.

Item Type:Article
Additional Information:Full text available in print and electronically from the School of Pharmacy Library.
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group
ID Code:1733
Journal or Publication Title:Journal of the American Chemical Society
Deposited By:Library Staff
Deposited On:11 Aug 2010 11:05
Last Modified:11 Aug 2010 11:05

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