Hazel, P., Huppert, J., Balasubramanian, S. and Neidle, S. (2004) Loop-length-dependent folding of G-quadruplexes. Journal of the American Chemical Society, 126 (50). pp. 16405-16415. 10.1021/ja045154j.
Full text not available from this repository.
Guanine-rich DNA sequences can form a large number of structurally diverse quadruplexes. These vary in terms of strand polarity, loop composition, and conformation. We have derived guidelines for understanding the influence of loop length on the structure adopted by intramolecular quadruplex-forming sequences, using a combination of experimental (using CD and UV melting data) and molecular modeling and simulation techniques. We find that a parallel-stranded intramolecular quadruplex structure is the only possible fold when three single residue loops are present. When single thymine loops are present in combination with longer length loops, or when all loops are longer than two residues, both parallel- and antiparallel-folded structures are able to form. Multiple conformations of each structure are likely to coexist in solution, as they were calculated to have very similar free energies.
|Additional Information:||Full text available in print and electronically from the School of Pharmacy Library.|
|Departments, units and centres:||Department of Pharmaceutical and Biological Chemistry > Cancer Research UK Biomolecular Structure Group|
|Journal or Publication Title:||Journal of the American Chemical Society|
|Deposited By:||Library Staff|
|Deposited On:||13 Aug 2010 10:14|
|Last Modified:||13 Aug 2010 10:57|
Item downloaded times since 13 Aug 2010 10:14.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item