Lombardo, C.M., Martínez, I.S., Haider, S.M., Gabelica, V., De Pauw, E., Moses, J.E. and Neidle, S. (2010) Structure-based design of selective high-affinity telomeric quadruplex-binding ligands. Chemical Communications, 46 (48). pp. 9116-9118. 10.1039/C0CC02917C.
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DOI: 10.1039/C0CC02917C
Abstract
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmaceutical and Biological Chemistry > Centre for Pharmacognosy and Phytotherapy |
| ID Code: | 1780 |
| Journal or Publication Title: | Chemical Communications |
| Deposited By: | Library Staff |
| Deposited On: | 24 Feb 2011 18:02 |
| Last Modified: | 13 Oct 2011 11:54 |
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