Al-Obaidi, H., Brocchini, S. and Buckton, G. (2009) Anomalous properties of spray dried solid dispersions. Journal of Pharmaceutical Sciences, 98 (12). pp. 4724-4737. doi:10.1002/jps.21782.
Full text not available from this repository.
The use of solid dispersions for oral dosage forms can increase the dissolution rate of poorly soluble drugs. Spray drying is one process that can be used to prepare solid dispersions. Spray dried solid dispersions of griseofulvin, poly[N-(2-hydroxypropyl)methacrylate] (PHPMA) and polyvinylpyrrolidone (PVP) were prepared from acetone and water. When methanol was substituted for water, the morphology, stability and dissolution properties of the solid dispersion changed dramatically. The glass transition temperature for the ternary solid dispersion (GF, PHPMA, and PVP) shifted from 83 degrees C (acetone/water) to 103 degrees C for the acetone/methanol system. These differences in the dispersions are thought to derive from conformational variations of the polymers in solution prior to spray drying. Both PHPMA and PVP formed globules in solution of a size range between 16 and 33 nm. The effect of drug and polymer concentration in solution (before spray drying) on the properties of the solid dispersion was studied. It was found that solid dispersions that were prepared using lower concentrations of drug and polymers in solutions resulted in the formation of particles that display a lower relaxation rate. This result supports the hypothesis that the polymer conformation may significantly change the properties of the solid dispersion.
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||Journal of Pharmaceutical Sciences|
|Deposited By:||Library Staff|
|Deposited On:||27 Feb 2011 18:55|
|Last Modified:||26 May 2011 14:38|
Item downloaded times since 27 Feb 2011 18:55.
Repository Staff Only: Item control page
School of Pharmacy Staff Only: Edit a copy to replace this item