Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense.

Wang, W., Zeng, Y.H., Osman, K., Shinde, K., Rahman, M.M., Gibbons, S. and Mu, Q. (2010) Norlignans, acylphloroglucinols, and a dimeric xanthone from Hypericum chinense. Journal of Natural Products, 73 (11). pp. 1815-1820. 10.1021/np1004483.

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DOI: 10.1021/np1004483

Abstract

Two new norlignans, hyperiones A (1) and B (2), three new acylphloroglucinols, aspidinol C (3) and hyperaspidinols A (5) and B (6), the known compound aspidinol D (4), and the symmetrical dimeric xanthone hyperidixanthone (7) were isolated from Hypericum chinense. Their structures were established by spectroscopic analysis. In an antibacterial assay using a panel of multidrug-resistant (MDR) strains, compounds 3 and 4 exhibited promising activity against the NorA efflux protein overexpressing MDR Staphylococcus aureus strain SA-1199B with a minimum inhibitory concentration (MIC) of 2 μg/mL (8.4 μM) and 4 μg/mL (16.8 μM), respectively. The positive control antibiotic norfloxacin showed activity at MIC 32 μg/mL (100 μM).

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1843
Journal or Publication Title:Journal of Natural Products
Deposited By:Library Staff
Deposited On:27 Feb 2011 19:25
Last Modified:27 Feb 2011 19:25

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