Mathematical Models of Skin Permeability: An Overview.

Mitragotri, S., Anissimov, Y.G., Bunge, A.L., Frasch, H.F., Guy, R.H., Hadgraft, J., Kasting, G.B., Lane, M.E. and Roberts, M.S. (2011) Mathematical Models of Skin Permeability: An Overview. International Journal of Pharmaceutics . 10.1016/j.ijpharm.2011.02.023.

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DOI: 10.1016/j.ijpharm.2011.02.023


Mathematical models of skin permeability play an important role in various fields including prediction of transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been performed over the last several decades to yield predictions of skin permeability to various molecules. These efforts include the development of empirical approaches such as quantitative structure-permeability relationships and porous pathway theories as well as the establishment of rigorous structure-based models. In addition to establishing the necessary mathematical framework to describe these models, efforts have also been dedicated to determining the key parameters that are required to use these models. This article provides an overview of various modeling approaches with respect to their advantages, limitations and future prospects.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1852
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:03 Mar 2011 12:10
Last Modified:03 Mar 2011 12:10


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