Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes

Bossche, J. van den, Al-Jamal, W.T., Tian, B., Nunes, A., Fabbro, C., Bianco, A., Prato, M. and Kostarelos, K. (2010) Efficient receptor-independent intracellular translocation of aptamers mediated by conjugation to carbon nanotubes. Chemical Communications, 46 (39). pp. 7379-7381. 10.1039/c0cc02092c.

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DOI: 10.1039/c0cc02092c

Abstract

We have covalently grafted aptamers onto carboxylated carbon nanotubes to design a novel vector system that can easily translocate into the cytosol of different cell types independent of receptor-mediated uptake. We propose the use of carbon nanotubes for the efficient intracellular delivery of biologically active aptamers for potential therapeutic applications.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Centre for Drug Delivery Research
ID Code:1872
Journal or Publication Title:Chemical Communications
Deposited By:Library Staff
Deposited On:03 Mar 2011 17:51
Last Modified:04 May 2012 11:18

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