'Poppy seeds' in stomach aspirates: is oral omeprazole extemporaneous dispersion bioavailable?

Tuleu, C., Arenas-Lopez, S., Robinson, C., McCarthy, D., Paget, R.I.J., Tibby, S. and Taylor, K.M.G. (2008) 'Poppy seeds' in stomach aspirates: is oral omeprazole extemporaneous dispersion bioavailable? European Journal of Pediatrics, 167 (7). pp. 823-5. 10.1007/s00431-007-0567-z .

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DOI: 10.1007/s00431-007-0567-z

Abstract

We report the appearance of 'poppy seed'-like structures found in the aspirated stomach contents and faeces of a 3-month-old infant receiving an omeprazole liquid via nasogastric tube, prepared by dispersing an omeprazole tablet (10 mg MUPS(R)) in water. Electron microscopy and mass spectroscopy indicated that these particles were hollow, dark purple coloured spheres comprising undissolved omeprazole and its degradation products. These observations suggest rapid degradation of omeprazole in the acid stomach contents, with compromised absorption of active drug. Consequently, dispersion of omeprazole in water may be an inappropriate formulation in this setting.

Item Type:Article
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1899
Journal or Publication Title:European Journal of Pediatrics
Deposited By:Library Staff
Deposited On:11 Mar 2011 09:03
Last Modified:11 Mar 2011 09:03

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