Inverse toroidal vesicles: precursors of tubules in sorbitan monostearate organogels

Murdan, S. (1999) Inverse toroidal vesicles: precursors of tubules in sorbitan monostearate organogels. International Journal of Pharmaceutics, 183 (1). p. 47. 10.1016/S0378-5173(99)00042-3.

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DOI: 10.1016/S0378-5173(99)00042-3


Sorbitan monostearate organogels are opaque, thermoreversible semi-solids whose microstructure consists of surfactant tubules dispersed in the organic continuous phase. Inverse toroidal vesicles are the precursors of the surfactant tubules. The gelation process was observed as an isotropic sol phase of sorbitan monostearate in isopropyl myristate was cooled using hot-stage light microscopy. At the gelation temperature, inverse toroidal vesicular structures were seen to grow in the organic phase. These toroids are thought to be analogous to other well-known vesicles, liposomes and niosomes, except for their toroidal (rather than spherical) shape and their inverse nature. They are rather short-lived structures: on further cooling of the sol phase, tubules form in the organic medium: it is speculated that the toroids elongate into tubular shapes or split into rod-shaped segments.

Item Type:Article
Uncontrolled Keywords:Organogel; Inverse vesicles; Toroids
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:1923
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:18 Mar 2011 10:50
Last Modified:18 Mar 2011 10:50

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