Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression.

Coon, H., Hicks, A.A., Bailey, M.E., Hoff, M., Holik, J., Harvey, R.J., Johnson, K.J., Darlison, M.G., Reimherr, F. and Wender, P. (1994) Analysis of GABAA receptor subunit genes in multiplex pedigrees with manic depression. Psychiatric Genetics, 4 (3). pp. 185-191.

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Abstract

The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of manic depression. Tests of this hypothesis can now be carried out due to the recent characterization of simple sequence repeat polymorphisms for the GABAA receptor alpha 1, alpha 2, alpha 4, alpha 5, alpha 6, beta 1, beta 3 and gamma 2 subunit genes. Using both parametric and non-parametric methods, we tested for linkage between manic depression and these polymorphisms in six multi-generational pedigrees. No evidence of linkage was found.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:1985
Journal or Publication Title:Psychiatric Genetics
Deposited By:Library Staff
Deposited On:31 Mar 2011 17:53
Last Modified:16 Jun 2011 11:07

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