Synapsins as mediators of BDNF-enhanced neurotransmitter release

Jovanovic, J.N., Czernik, A.J., Fienberg, A.A., Greengard, P. and Sihra, T.S. (2000) Synapsins as mediators of BDNF-enhanced neurotransmitter release. Nature Neuroscience, 3 (4). pp. 323-329. 10.1038/73888.

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DOI: 10.1038/73888

Abstract

We examined enhancement of synaptic transmission by neurotrophins at the presynaptic level. In a synaptosomal preparation, brain-derived neurotrophic factor (BDNF) increased mitogen-activated protein (MAP) kinase-dependent synapsin I phosphorylation and acutely facilitated evoked glutamate release. PD98059, used to inhibit MAP kinase activity, markedly decreased synapsin I phosphorylation and concomitantly reduced neurotransmitter release. The stimulation of glutamate release by BDNF was strongly attenuated in mice lacking synapsin I and/or synapsin II. These results indicate a causal link of synapsin phosphorylation via BDNF, TrkB receptors and MAP kinase with downstream facilitation of neurotransmitter release.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2024
Journal or Publication Title:Nature Neuroscience
Deposited By:Library Staff
Deposited On:07 Apr 2011 11:58
Last Modified:08 Apr 2011 17:10

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