Xu, H.X., Gouras, G.K., Greenfield, J.P., Vincent, B., Naslund, J., Mazzarelli, L., Fried, G., Jovanovic, J.N., Seeger, M., Relkin, N.R., Liao, F., Checler, F., Buxbaum, J.D., Chait, B.T., Thinakaran, G., Sisodia, S.S., Wang, R., Greengard, P. and Gandy, S. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Medicine, 4 (4). pp. 447-451. 10.1038/nm0498-447 .
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DOI: 10.1038/nm0498-447
Abstract
Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid beta-amyloid (A beta) peptides, and autosomal dominant forms of AD appear to cause disease by promoting brain A beta accumulation. Recent studies indicate that postmenopausal estrogen replacement therapy may prevent or delay the onset of AD. Here we present evidence that physiological levels of 17 beta-estradiol reduce the generation of A beta by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons. These results suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.
| Item Type: | Article |
|---|---|
| Departments, units and centres: | Department of Pharmacology > Department of Pharmacology |
| ID Code: | 2027 |
| Journal or Publication Title: | Nature Medicine |
| Deposited By: | Library Staff |
| Deposited On: | 07 Apr 2011 12:43 |
| Last Modified: | 07 Apr 2011 12:43 |
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