Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides

Xu, H.X., Gouras, G.K., Greenfield, J.P., Vincent, B., Naslund, J., Mazzarelli, L., Fried, G., Jovanovic, J.N., Seeger, M., Relkin, N.R., Liao, F., Checler, F., Buxbaum, J.D., Chait, B.T., Thinakaran, G., Sisodia, S.S., Wang, R., Greengard, P. and Gandy, S. (1998) Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nature Medicine, 4 (4). pp. 447-451. 10.1038/nm0498-447 .

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DOI: 10.1038/nm0498-447

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid beta-amyloid (A beta) peptides, and autosomal dominant forms of AD appear to cause disease by promoting brain A beta accumulation. Recent studies indicate that postmenopausal estrogen replacement therapy may prevent or delay the onset of AD. Here we present evidence that physiological levels of 17 beta-estradiol reduce the generation of A beta by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons. These results suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2027
Journal or Publication Title:Nature Medicine
Deposited By:Library Staff
Deposited On:07 Apr 2011 12:43
Last Modified:07 Apr 2011 12:43

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