Dendritic ion channel trafficking and plasticity

Shah, M.M., Hammond, R.S. and Hoffman, D.A. (2010) Dendritic ion channel trafficking and plasticity. Trends in Neurosciences, 33 (7). pp. 307-316. 10.1016/j.tins.2010.03.002.

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DOI: 10.1016/j.tins.2010.03.002

Abstract

Dendritic ion channels are essential for the regulation of intrinsic excitability as well as modulating the shape and integration of synaptic signals. Changes in dendritic channel function have been associated with many forms of synaptic plasticity. Recent evidence suggests that dendritic ion channel modulation and trafficking may contribute to plasticity-induced alterations in neuronal function. In this review, we discuss our current knowledge of dendritic ion channel modulation and trafficking and their relationship to cellular and synaptic plasticity. We also consider the implications for neuronal function. We argue that to gain an insight into neuronal information processing, it is essential to understand the regulation of dendritic ion channel expression and properties.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2038
Journal or Publication Title:Trends in Neurosciences
Deposited By:Library Staff
Deposited On:05 May 2011 09:30
Last Modified:05 May 2011 09:30

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