Tritylamino Aromatic Heterocycles and Related Carbinols as Blockers of Ca 2+-Activated Potassium Ion Channels Underlying Neuronal Hyperpolarization

Zunszain, P.A., Shah, M.M., Miscony, Z., Javadzadeh-Tabatabaie, M., Haylett, D.G. and Ganellin, C.R. (2002) Tritylamino Aromatic Heterocycles and Related Carbinols as Blockers of Ca 2+-Activated Potassium Ion Channels Underlying Neuronal Hyperpolarization. Archiv der Pharmazie, 335 (4). pp. 159-166.

Full text not available from this repository.

Abstract

A series of novel aromatic tritylamino heterocycles has been synthesized and the compounds have been tested in comparison with clotrimazole for their ability to inhibit the slow afterhyperpolarization current (sI (AHP)) in cultured rat hippocampal pyramidal neurones. Some analogues of the clotrimazole metabolite, 2-chlorophenyl-diphenyl methanol, having different chlorination substitution in the triphenyl group have also been examined. Two compounds in particular, 3-[(2-chlorophenyl)-diphenylmethylamino] pyridine (3a, UCL 1880) and 2-tritylaminothiazole (6, UCL 2027), are of special interest; they are effective blockers of the sI (AHP) (IC (50) = 1.1-1.2 microM) and are much more selective than clotrimazole since they have less effect on the high voltage-activated Ca2+ current.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Department of Pharmacology
ID Code:2040
Journal or Publication Title:Archiv der Pharmazie
Deposited By:Library Staff
Deposited On:05 May 2011 09:47
Last Modified:05 May 2011 09:47

Repository Staff Only: Item control page

School of Pharmacy Staff Only: Edit a copy to replace this item