Pharmaceutical physical form characterisation with fast (>200 °C min−1) DSC heating rates

Gaisford, S. and Buanz, A.B. (2011) Pharmaceutical physical form characterisation with fast (>200 °C min−1) DSC heating rates. Journal of Thermal Analysis and Calorimetry . 10.1007/s10973-011-1573-y.

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DOI: 10.1007/s10973-011-1573-y


Differential scanning calorimetry (DSC) has many applications during preformulation screening of new drug candidates, but definitive assignment of peaks to specific events in the sample is difficult without supplementary data from other techniques. To some extent these problems can be overcome by running multiple experiments at different heating rates. Typically 2 and 20 °C min−1 are indicated. However, modern instruments are capable of achieving much faster heating rates (up to 750 °C commercially); with this extended range comes a new capacity for investigating the physical form of materials. Here, the use of fast DSC heating rates for materials characterisation is explored, focussing on determination of melting temperatures, glass formation and polymorph screening.

Item Type:Article
Uncontrolled Keywords:Fast-scan differential scanning calorimetry – Preformulation – Pharmaceutical – Polymorphism – Co-crystals
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2088
Journal or Publication Title:Journal of Thermal Analysis and Calorimetry
Deposited By:Library Staff
Deposited On:19 May 2011 14:17
Last Modified:19 May 2011 14:17

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