A comparative study on the pulmonary delivery of tobramycin encapsulated into liposomes and PLA microspheres following intravenous and endotracheal delivery

Poyner, E., Alpar, H.O., Almeida, A.J., Gamble, M.D. and Brown, M.R.W. (1995) A comparative study on the pulmonary delivery of tobramycin encapsulated into liposomes and PLA microspheres following intravenous and endotracheal delivery. Journal of Controlled Release, 35 (1). pp. 41-48. 10.1016/0168-3659(95)00017-3.

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DOI: 10.1016/0168-3659(95)00017-3

Abstract

The use of carriers to deliver tritiated tobramycin via intravenous and endotracheal routes to the lungs was investigated. Pulmonary, renal and vascular distribution were monitored at 6 and 24 h. The results indicated a significant difference (p < 0.05) between free drug, which is rapidly disseminated to other organs, specifically kidney, and liposomal and microcapsular tobramycin which was primarily retained in the lungs. Renal drug levels of intravenously delivered microcapsular tobramycin were significantly higher than those produced by liposomal administration at 6 (p ≤ 0.025) and 24 h (p ≤ 0.05). Liposomes however, produced pulmonary levels three times higher than those of the free drug both at 6 (p ≤ 0.025) and 24 h (p ≤ 0.025). At 24 h renal drug levels following endotracheal delivery were lower for both encapsulated forms than for the free drug (p ≤ 0.005). Conversely, pulmonary drug levels were higher following encapsulated drug administration compared to those following free drug delivery at 24 h (p ≤ 0.005). These results demonstrate that tobramycin can be retained in the lung by means of liposomal and microencapsulated delivery systems after endotracheal delivery.

Item Type:Article
Uncontrolled Keywords:Phosphatidylcholine liposome; PLA microcapsule; Tobramycin; Intravenous; Endotracheal delivery
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2106
Journal or Publication Title:Journal of Controlled Release
Deposited By:Library Staff
Deposited On:20 May 2011 11:45
Last Modified:20 May 2011 12:48

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