New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model

Florindo, H., Pandit, S., Goncalves, L., Alpar, H.O. and Almeida, A.J. (2009) New approach on the development of a mucosal vaccine against strangles: Systemic and mucosal immune responses in a mouse model. Vaccine, 27 (8). pp. 1230-1241. 10.1016/j.vaccine.2008.12.004.

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DOI: 10.1016/j.vaccine.2008.12.004

Abstract

Streptococcus equi subspecies equi affects animals of Equidae family and is the causative agent of strangles, an acute, extremely contagious and deadly disease. Prolonged periods of protection associated to absence of serious adverse reactions were not yet achieved. Thus, this experimental work is focused on the study of mucosal, humoral and cellular immune responses developed in a mouse model, after the intranasal administration of S. equi antigens associated by adsorption or encapsulation to poly(lactic acid) nanospheres, modified by mucoadhesive polymers and absorption enhancers. Particles fitted the nanometer range and proteins integrity and antigenicity were not affected. PLA nanospheres induced a mixed Th1 and Th2 response, being therefore potential carriers for the delivery of S. equi antigens.

Item Type:Article
Uncontrolled Keywords:Poly(lactic acid); Nanospheres; Strangles; Mucosal vaccine
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2108
Journal or Publication Title:Vaccine
Deposited By:Library Staff
Deposited On:20 May 2011 12:54
Last Modified:20 May 2011 12:54

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