Effectiveness of liposomes as adjuvants of orally and nasally administered tetanus toxoid

Alpar, H.O., Bowen, J. and Brown, M.R.W. (1992) Effectiveness of liposomes as adjuvants of orally and nasally administered tetanus toxoid. International Journal of Pharmaceutics, 88 (1-3). pp. 335-344. 10.1016/0378-5173(92)90332-V.

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DOI: 10.1016/0378-5173(92)90332-V


Tetanus toxoid was incorporated into liposomes of equimolar concentrations of distearoyl phosphadylcholine (DSPC) and cholesterol. We investigated the non-parenteral delivery of free or liposome entrapped tetanus toxoid to guinea pigs and measured the subsequent IgG anti-tetanus-antibody response, using an ELISA. Liposome formulation significantly improved the immune response when compared to the free antigen when delivered via the nasal, oral and i.m. routes. However, 10 × concentration of tetanus toxoid entrapped in DSPC introduced mucosally (nasally and orally) was necessary to produce an IgG antibody titre similar to those obtained via the i.m. delivery. This study suggests that liposomes, administered through the oral and nasal routes, have considerable potential as mucosal adjuvants and warrant further investigation.

Item Type:Article
Uncontrolled Keywords:Liposome; Oral administration; Nasal administration; Mucosal delivery; Antigen; Immune response
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2117
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:20 May 2011 14:52
Last Modified:20 May 2011 14:52

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