Alpar, H.O., Bason, A., Hickman, J., Richards, F. and Field, W. (1990) Estimation by FACS of the delivery of liposome encapsulated macromolecules into myeloid cells. International Journal of Pharmaceutics, 62 (2-3). pp. 133-141. 10.1016/0378-5173(90)90227-U.
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DOI: 10.1016/0378-5173(90)90227-U
Abstract
Charged and neutral liposomes were loaded with fluorescein (FITC) labelled albumin. The extent to which the FITC-albumin delivered to non-phagocytic HL-60 cells, zeta potential − 9.8 mV, by the process of fusion, was monitored using both a microscope and flow cytometry (FACS). Positively charged liposomes were most effective in their delivery whilst those with a negative charge showed very little transference ability. The delivery of FITC-albumin from positively charged liposomes was found to be heterogeneous with regard to cell size in the absence of PEG, and more homogeneous in the presence of the fusogen.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Liposome; Non-phagocytic cell; Delivery; Macromolecule; Cell surface; Membrane fusion; Fusogen; Flow cytometry |
| Departments, units and centres: | Department of Pharmaceutics > Department of Pharmaceutics |
| ID Code: | 2120 |
| Journal or Publication Title: | International Journal of Pharmaceutics |
| Deposited By: | Library Staff |
| Deposited On: | 20 May 2011 15:16 |
| Last Modified: | 20 May 2011 15:16 |
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