Alpar, H.O., Bason, A., Hickman, J., Richards, F. and Field, W. (1990) Estimation by FACS of the delivery of liposome encapsulated macromolecules into myeloid cells. International Journal of Pharmaceutics, 62 (2-3). pp. 133-141. 10.1016/0378-5173(90)90227-U.
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Charged and neutral liposomes were loaded with fluorescein (FITC) labelled albumin. The extent to which the FITC-albumin delivered to non-phagocytic HL-60 cells, zeta potential − 9.8 mV, by the process of fusion, was monitored using both a microscope and flow cytometry (FACS). Positively charged liposomes were most effective in their delivery whilst those with a negative charge showed very little transference ability. The delivery of FITC-albumin from positively charged liposomes was found to be heterogeneous with regard to cell size in the absence of PEG, and more homogeneous in the presence of the fusogen.
|Uncontrolled Keywords:||Liposome; Non-phagocytic cell; Delivery; Macromolecule; Cell surface; Membrane fusion; Fusogen; Flow cytometry|
|Departments, units and centres:||Department of Pharmaceutics > Department of Pharmaceutics|
|Journal or Publication Title:||International Journal of Pharmaceutics|
|Deposited By:||Library Staff|
|Deposited On:||20 May 2011 15:16|
|Last Modified:||20 May 2011 15:16|
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