A biomedical library of serinol-derived polyesters

Rickerby, J., Prabhakar, R., Patel, A.V., Knowles, J. and Brocchini, S. (2005) A biomedical library of serinol-derived polyesters. Journal of Controlled Release, 101 (1-3). pp. 21-34. 10.1016/j.jconrel.2004.07.021.

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DOI: 10.1016/j.jconrel.2004.07.021

Abstract

Polyesters derived from glycerol and serinol were prepared. These polyesters were designed to be potential surrogate polymers for poly(glycolic acid) (PGA) to extend the properties that aliphatic biomedical polyesters could encompass. The 1- and 2-substituted glycerol derived monomers were liquids and difficult to polymerize reproducibly. In contrast the N-substituted serinol monomers were solids and easy to prepare. Each of the four N-substituted serinol-diol monomers was polymerized in a parallel fashion with each of the four commercially available diacids to produce a small library of 16 polyesters. Glass transition and contact angle values were determined to ascertain structure–property correlations due to defined chemical changes in the polymer mainchain and pendent chain. A serinol-derived precursor polymer was also prepared.

Item Type:Article
Uncontrolled Keywords:Serinol; Polymer; PGA
Departments, units and centres:Department of Pharmaceutics > Department of Pharmaceutics
ID Code:2135
Journal or Publication Title:Journal of Controlled Release
Deposited By:Library Staff
Deposited On:26 May 2011 10:53
Last Modified:26 May 2011 10:53

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