Effect of Vitamin E TPGS on immune response to nasally delivered diphtheria toxoid load poly(caprolactone) microparticles

Somavarapu, S., Pandit, S., Gradassi, G., Bandera, M., Ravichandran, E. and Alpar, H.O. (2005) Effect of Vitamin E TPGS on immune response to nasally delivered diphtheria toxoid load poly(caprolactone) microparticles. International Journal of Pharmaceutics, 298 (2). pp. 344-347. 10.1016/j.ijpharm.2005.03.029 .

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DOI: 10.1016/j.ijpharm.2005.03.029

Abstract

The nasal mucosa has many advantages as a potential site for drug and vaccine delivery. The present study has sought to exploit this route of delivery using microparticles composed of d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) as a matrix material blended with poly(caprolactone) for nasal immunisation with diphtheria toxoid. Particles were prepared by a double emulsion method, followed by spray drying and the effect of TPGS on size, zeta potential, loading and release of antigen was assessed. Particles composed of TPGS–PCL blends were spherical, smooth and monodisperse, displaying increasing yields after spray drying with increasing concentrations of TPGS. The immune response to diphtheria toxoid loaded PCL-TPGS microspheres after nasal administration was shown to be higher than that achieved using PCL microspheres alone. We conclude that TPGS shows significant potential as a novel adjuvant either alone or in combination with an appropriate delivery system.

Item Type:Article
Additional Information:Full text available in print and electronically at the School of Pharmacy Library.
Uncontrolled Keywords:Microspheres; Vitamin E TPGS; PCL; Emulsification; Spray drying; Diphtheria toxoid; Intra nasal
Departments, units and centres:Department of Pharmaceutics > Centre for Drug Delivery Research
ID Code:214
Journal or Publication Title:International Journal of Pharmaceutics
Deposited By:Library Staff
Deposited On:10 Oct 2006
Last Modified:18 Nov 2011 09:36

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