Hypericin as a non-antioxidant inhibitor of NF-kappa B.

Bork, P.M., Bacher, S., Schmitz, M.L., Kaspers, U. and Heinrich, M. (1999) Hypericin as a non-antioxidant inhibitor of NF-kappa B. Planta Medica, 65 (4). pp. 297-300. 10.1055/s-1999-13989.

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DOI: 10.1055/s-1999-13989

Abstract

NF-kappa B is a transcription factor involved in immune and inflammatory responses. Here we show that micromolar concentrations of hypericin inhibited the PMA- and TNF-alpha-induced activation of NF-kappa B in HeLa and TC10 cells, respectively. In contrast, NF-kappa B activated by H2O2 was not influenced by hypericin, indicating a pathway-specificity of hypericin. Hyperforin and a Hypericum perforatum extract standardised on 0.15% hypericin and 5% hyperforin were not active at pharmacologically relevant concentrations. The PMA/TNF-alpha-induced transcription of a reporter gene, which is under the control of the NF-kappa B-dependent IL-6 promoter, was strongly reduced by preincubation with hypericin.

Item Type:Article
Departments, units and centres:Department of Pharmaceutical and Biological Chemistry > Department of Pharmaceutical and Biological Chemistry
ID Code:2156
Journal or Publication Title:Planta Medica
Deposited By:Library Staff
Deposited On:09 Jun 2011 17:26
Last Modified:09 Jun 2011 17:27

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