Butler, J.A., Peveler, R.C., Roderick, P., Horne, R. and Mason, J.C. (2004) Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring. Transplantation, 77 (5). pp. 786-789.
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Nonadherence to immunosuppressants in renal transplant recipients is a major factor affecting graft survival, but it is difficult to detect accurately in clinical practice. Adherence was measured in 153 adult renal transplant recipients using self-report questionnaires and interview, clinician rating, and cyclosporine levels. The sensitivity and specificity of these measures were determined by comparison with electronic monitoring in a randomly selected subsample of 58 subjects. Measures of adherence in current clinical use do not perform well when tested against electronic monitoring. Self-report at a confidential interview was the best measure of adherence for the detection of both missed doses and erratic timing of medication. However, the use of a confidential interview is not directly applicable to a clinical setting. Further research on how best to facilitate disclosure in clinical settings may be the best way to develop adherence measures for use in routine practice.
|Departments, units and centres:||Department of Practice and Policy > Centre for Behavioural Medicine|
|Journal or Publication Title:||Transplantation|
|Deposited By:||Library Staff|
|Deposited On:||16 Jun 2011 17:29|
|Last Modified:||16 Jun 2011 17:29|
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