Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery

Alpar, H.O., Somavarapu, S., Atuah, K.N. and Bramwell, V.W. (2005) Biodegradable mucoadhesive particulates for nasal and pulmonary antigen and DNA delivery. Advanced Drug Delivery Reviews, 57 (3). pp. 411-430. 10.1016/j.addr.2004.09.004.

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DOI: 10.1016/j.addr.2004.09.004


Biodegradable polymer and particulate carriers have been shown to be of considerable potential for the delivery of peptides, proteins and DNA in animal models. In the context of vaccine delivery to the upper and lower respiratory tracts, the use of mucoadhesive agents offers a strategy for the facilitation of increased residence time and increased vaccine efficacy. Additional concerns addressed here include the potential of uptake of vaccine formulations by the primary olfactory nerves in the nasal cavity, effective delivery to the lung, strategies to maximise the immunopotentiation of candidate vaccine formulations, as well as the evaluation of animal models and interpretation of engendered immune responses in terms of antigen-specific antibody production. Experimental data are presented that demonstrate the potential of muco- and bioadhesive agents in combination with liposomes for intranasal (i.n.) delivery of tetanus toxoid in mice. A delivery system utilising chitosan for the formulation of microspheres by the spray-drying method is described and assessed for intranasal vaccine delivery, and porous particles with potential for pulmonary administration are also outlined.

Item Type:Article
Additional Information:Full text available in print and electronically at the School of Pharmacy Library.
Uncontrolled Keywords:Vaccine delivery; DNA vaccine; Protein/peptide delivery; Mucosal immunology; Vaccination strategy; Particulate delivery systems
Departments, units and centres:Department of Pharmaceutics > Centre for Drug Delivery Research
ID Code:219
Journal or Publication Title:Advanced Drug Delivery Reviews
Deposited By:Library Staff
Deposited On:17 Sep 2007
Last Modified:18 Nov 2011 09:41

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