Statistical power considerations show the endocrine disruptor low-dose issue in a new light.

Scholze, M. and Kortenkamp, A. (2007) Statistical power considerations show the endocrine disruptor low-dose issue in a new light. Environmental Health Perspectives, 115 (Suppl 1). pp. 84-90. 10.1289/ehp.9364.

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DOI: 10.1289/ehp.9364

Abstract

We demonstrate that low-dose estimates such as the no observed adverse effect levels derived from statistical hypothesis-testing procedures are dependent on the specific experimental conditions used for testing. Thus, below the statistical detection limit of the experiment, the presence of effects can neither be proven nor ruled out. Common practice is to attempt to establish "doses without effect." However, low-dose estimations in the endocrine-disruptor field could be improved if decisions regarding the toxicologic effect size of relevance formed the starting point of testing procedures. Statistical power considerations could then reveal the resources necessary to demonstrate effect magnitudes of concern.

Item Type:Article
Uncontrolled Keywords:benchmark, endocrine disruptors, LOEL, low-dose, NOEL, regression, threshold
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:2247
Journal or Publication Title:Environmental Health Perspectives
Deposited By:Library Staff
Deposited On:23 Jun 2011 12:13
Last Modified:23 Jun 2011 12:13

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