Silva, E., Scholze, M. and Kortenkamp, A. (2007) Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay. Environmental Health Perspectives, 115 Suppl 1 . pp. 91-97. 10.1289/ehp.9363.
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Our studies illustrate the difficulties that may be encountered during the estimation of low doses in vivo. High statistical power is required when the underlying dose-response curves are shallow. Through the use of large sample sizes and numerous repeats, the experimental power of the E-Screen assay was sufficiently high to measure effect magnitudes of around 1-2% with reliability. However, such resources are usually not available for in vivo testing, with the consequence that the statistical detection limits are considerably higher. If this coincides with shallow dose-response curves in the low-effect range (which is normally not measurable in vivo), the limited resolving power of in vivo assays may seriously constrain low-dose testing.
|Departments, units and centres:||Department of Pharmacology > Centre for Toxicology|
|Journal or Publication Title:||Environmental Health Perspectives|
|Deposited By:||Library Staff|
|Deposited On:||23 Jun 2011 12:22|
|Last Modified:||23 Jun 2011 12:22|
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