Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay.

Silva, E., Scholze, M. and Kortenkamp, A. (2007) Activity of xenoestrogens at nanomolar concentrations in the E-Screen assay. Environmental Health Perspectives, 115 Suppl 1 . pp. 91-97. 10.1289/ehp.9363.

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DOI: 10.1289/ehp.9363

Abstract

Our studies illustrate the difficulties that may be encountered during the estimation of low doses in vivo. High statistical power is required when the underlying dose-response curves are shallow. Through the use of large sample sizes and numerous repeats, the experimental power of the E-Screen assay was sufficiently high to measure effect magnitudes of around 1-2% with reliability. However, such resources are usually not available for in vivo testing, with the consequence that the statistical detection limits are considerably higher. If this coincides with shallow dose-response curves in the low-effect range (which is normally not measurable in vivo), the limited resolving power of in vivo assays may seriously constrain low-dose testing.

Item Type:Article
Departments, units and centres:Department of Pharmacology > Centre for Toxicology
ID Code:2248
Journal or Publication Title:Environmental Health Perspectives
Deposited By:Library Staff
Deposited On:23 Jun 2011 12:22
Last Modified:23 Jun 2011 12:22

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